![]() Critical study details were frequently unreported, including the mechanism for patient/sample selection and researcher blinding to results, which lead to concern for bias.Ĭurrent studies estimating test performance characteristics have imperfect study design and statistical methods for the estimation of test performance characteristics of SARS-CoV-2 tests. We conducted a narrative and tabular synthesis of studies organized by their reference standard strategy or comparative agreement method, resulting in six categorizations. Studies were evaluated using elements of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) guidelines. Studies of any design that performed tests on ≥10 patients and reported or inferred correlative statistics were included. We conducted a systematic search of English-language articles published December 31, 2019-June 19, 2020. Electronic address: assess the methodologies used in the estimation of diagnostic accuracy of SARS-CoV-2 real-time reverse transcription polymerase chain reaction (rRT-PCR) and other nucleic acid amplification tests (NAATs) and to evaluate the quality and reliability of the studies employing those methods. 6 Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1155 Pressler St., Unit 1340, Houston, TX 77030, USA.5 School of Social Sciences, Rice University, MS 272, 5620 Greenbriar Dr, Houston, TX 77005, USA.DeBakey VA Medical Center, 2450 Holcombe Blvd, Houston, TX, 77021, USA. ![]() 4 Section of Infectious Diseases, Department of Internal Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Houston HSR&D IQuESt, Michael E.3 School of Social Sciences, Rice University, MS 272, 5620 Greenbriar Dr, Houston, TX 77005, USA UTHealth School of Public Health, Houston, TX, USA.2 Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA School of Social Sciences, Rice University, MS 272, 5620 Greenbriar Dr, Houston, TX 77005, USA UTHealth School of Public Health, Houston, TX, USA.1 Section of Infectious Diseases, Department of Internal Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
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